NEUROTOXIC SYNDROME PRODUCED IN CHICKENS BY A CYCLIC PHOSPHATE METABOLITE OF TRI-o-CRESYL PHOSPHATE-A CLINICAL AND PATHOLOGICAL STUDY

The absorption of tri-ortho-cresyl phosphate through the skin of hens and its neurotoxic effects.

General and neurotoxic effects of ingested triortho-cresyl phosphate *(TOCP) in man and animals have been described in detail for the last 20 years. We refer here only briefly to the clinical literature where TOCP was implicated, such as Jamaica ginger paralysis in America (Aring, Bean, Roseman, Rosenbaum, and Spies, 1941; Aring, 1942); the massive intoxications by engine oil at the beginning o...

[A case of tri-ortho-cresyl-phosphate poisoning].

Tri-cresyl phosphate neuropathy in Sri Lanka: a clinical and neurophysiological study with a three year follow up.

Clinical and neurophysiological findings in twenty patients intoxicated with tri-cresyl phosphate following consumption of contaminated gingili oil are reported. Marked distal axonopathy, high incidence of pyramidal tract dysfunction and minimal sensory abnormalities were the cardinal features. Despite pronounced motor weakness in the early stages, the patients showed remarkable improvement dur...

Interim Specific Ground Water Criterion - Tri-ortho-cresyl phosphate (TOCP)

Disturbed phospholipid homeostasis in endoplasmic reticulum initiates tri-o-cresyl phosphate-induced delayed neurotoxicity

Tri-o-cresyl phosphate (TOCP) is a widely used organophosphorus compound, which can cause a neurodegenerative disorder, i.e., organophosphate-induced delayed neurotoxicity (OPIDN). The biochemical events in the initiation of OPIDN were not fully understood except for the essential inhibition of neuropathy target esterase (NTE). NTE, located in endoplasmic reticulum (ER), catalyzes the deacylati...